Desert Fossil sits in the Early Hardmode tier of Terraria progression based on its rarity rating (4).
Mythical is the strongest prefix for Desert Fossil — +15% damage, +10% speed, +10% crit, +15% knockback, −15% mana.
Desert Fossil deals 40 base damage, 10-tick use time. Use the DPS calculator to see expected damage per second with prefixes and crit applied.
Desert Fossil is used as an ingredient in 1 recipe. See the "Used to craft" section above for the full list.